Artichoke Extract

Overview

Artichoke extract, derived from the Cynara scolymus plant, is a herbal supplement used for various health benefits. Traditionally, artichokes have been consumed as a vegetable and used medicinally to aid digestion and liver health. The extract is primarily made from the leaves, stems, and roots of the plant, which contain compounds like cynarin, chlorogenic acid, and flavonoids^[1][2]. Historically, artichokes have been cultivated in the Mediterranean region since ancient times, valued for their digestive and medicinal properties^[1].

Forms and Variations

Artichoke extract is available in several forms, including powders, tablets, capsules, and juices. The formulations can vary based on the part of the plant used (leaves, stems, roots) and the extraction method (aqueous or dried extractions)^[1]. The choice of form may depend on personal preference or specific health needs, such as digestive issues or cholesterol management.

Dosage and Administration

The dosage of artichoke extract varies widely, ranging from 4.33 to 3,000 mg per day, depending on the intended use and formulation^[1]. For conditions like indigestion, doses of 320-640 mg three times daily are common, while for cholesterol management, higher doses around 1,800-1,920 mg per day are used^[3]. It is recommended to consult a healthcare provider for personalized dosing.

Scientific Research and Mechanism of Action

Artichoke extract has been studied for its antioxidant, choleretic (bile-stimulating), and hepatoprotective effects^[5]. It works by enhancing bile secretion, which aids digestion and may help lower cholesterol levels by reducing its synthesis in the liver^[2]. Research supports its use in improving liver function and reducing symptoms of indigestion^[3]. However, more studies are needed to confirm its effectiveness for other potential benefits.

Benefits and Potential Uses

Artichoke extract is known to improve digestion by reducing symptoms of indigestion and may help lower cholesterol levels^[3]. It also shows promise in supporting liver health and potentially aiding conditions like non-alcoholic fatty liver disease^[1]. Additionally, it may help manage blood pressure and improve metabolic health, though more evidence is needed for these uses^[1].

Side Effects and Risks

Common side effects of artichoke extract are generally mild and may include gastrointestinal upset. However, individuals with allergies to plants in the Asteraceae family should exercise caution^[2]. There is limited information on severe risks, but as with any supplement, it is advisable to consult a healthcare provider before use.

Interactions and Precautions

Artichoke extract may interact with certain medications, such as blood thinners or diabetes medications, due to its potential effects on blood sugar and clotting^[2]. Pregnant or breastfeeding women should consult a healthcare provider before using artichoke supplements.

Impact on Biomarkers

Artichoke extract may influence biomarkers related to liver health, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), by reducing their levels, indicating improved liver function^[2]. It may also affect cholesterol levels, potentially lowering LDL cholesterol^[3].

Overdose and Toxicity

There is limited data on the toxicity of artichoke extract, but high doses may exacerbate gastrointestinal side effects. It is essential to follow recommended dosages and consult a healthcare provider if concerns arise^[2].

Disclaimer

The information provided in this document is for educational purposes only and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.